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It recognizes an intermediate filament protein (IFP) of 55kDa, which is identified as cytokeratin 7. This mAb is highly specific to cytokeratin 7 and shows no cross-reaction with other IFPs. Cytokeratin 7 is a basic cytokeratin, which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Keratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not of colon, prostate, or gastrointestinal tract.This mAb is highly useful in distinguishing ovarian carcinomas (keratin 7+) from colon carcinomas (keratin 7-).
Optimal dilution of the recombinant KRT7 antibody should be determined by the researcher.
Recombinant full-length human KRT7 protein was used as the immunogen for the recombinant KRT7 antibody.
Aliquot the recombinant KRT7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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